Under the terms of the agreement, Spark Therapeutics will receive access to NeuExcell’s proprietary neuro-regenerative gene therapy platform and capabilities. NeuExcell’s research team will collaborate closely with Spark Therapeutics to advance the program. Under the Option License NeuExcell is eligible to receive upfront, license fees, R&D and Sales milestone payments up to approximately $190 million plus product royalties. Under this Agreement, Spark Therapeutics has the option to license the exclusive worldwide rights of the NeuExcell’s HD program.

“We are excited to collaborate with Spark Therapeutics. Their in-house know-how and capabilities to develop gene therapies that may have the potential to slow, halt or cure neurological diseases and seek to enhance the industry standard for AAV engineering, making them an ideal partner to accelerate our HD program,” said Ronald HW Lorijn, CEO of NeuExcell Therapeutics.

“Spark Therapeutics is always looking for ways to bring potentially groundbreaking therapies to patients, including those living with Huntington’s Disease, to challenge the inevitability of genetic diseases. We are looking forward to our collaboration with NeuExcell and to explore their unique neuroregenerative gene therapy platform,” said Federico Mingozzi, Ph.D., Chief Scientific Officer of Spark Therapeutics.

The prevailing assumption has been that mammalian adult neurons cannot be replaced, and so therapeutic approaches for brain diseases tend to focus on slowing disease progress. NeuExcell Therapeutics may have unlocked the method for regenerating neural tissue. The company’s neuroregenerative gene therapy platform is built around transcription factor-based trans-differentiation technology. The platform seeks to reprogram endogenous glial cells like astrocytes, which surround neurons and are often reactive after neurons are injured or die, into functional new neurons. While neurons cannot divide to regenerate themselves, glial cells are a renewable source for generating new neurons at the site of injury, and at the scale needed to have a meaningful therapeutic impact. NeuExcell is developing adeno-associated viruses (AAVs)-based neuroregenerative gene therapy to regenerate functional new neurons at the site of the neurodegeneration.

“At Spark, we understand that in order to break down barriers for people and families affected by genetic diseases, we need to work with like-minded partners that can integrate innovative technologies with our advanced proprietary AAV vector platform,” said Joseph La Barge, Chief Business Officer of Spark Therapeutics. “Using our existing expertise in gene therapy development and NeuExcell’s neuro-regenerative gene therapy research and capabilities, together we can progress the potential of gene therapy for patients living with Huntington’s Disease.”

Spark Therapeutic’s advanced proprietary AAV vector platform targeted to the central nervous system offers the HD research and development (R&D) program a major advantage. At the forefront of gene therapy research for more than two decades, Spark Therapeutics has extensive knowledge and capabilities in this field that it will use to bring the HD program forward.

The post NeuExcell Therapeutics and Spark Therapeutics Announce Research Collaboration Agreement to Develop a Novel Gene Therapy for Huntington’s Disease appeared first on Enterprise Viewpoint.

Allied Market Research published a report, titled, “Styrenics Market By Wattage (Low Power, Medium Power, and High Power), Spectrum (Narrow and Broad), Installation Type (New Installation and Retrofit), and Application (Indoor Farming, Commercial Greenhouse, Vertical Farming, Turf and Landscaping, Research, and Others): Global Opportunity Analysis and Industry Forecast, 2021–2030.” According to the report, the global styrenics industry generated $76.6 billion in 2020, and is expected to garner $134.9 billion by 2030, witnessing a CAGR of 5.9% from 2021 to 2030.

Prime determinants of growth

Rising demand in the application of the wind energy, surge in application in automobile industry, and growth in demand for various plastic in consumer sector drive the growth of the global styrenics market. However, surge in environment and healthcare concerns hinder the market growth. On the other hand, rapid development of infrastructure in developing countries presents new opportunities in the coming years.

Covid-19 Scenario

The styrenics market witnessed a negative impact of the covid-19 outbreak. The lockdown resulted in suspension of production facilities and disruptions in the supply chain.
Furthermore, declined demand from the end-using industries including automotive, construction, and consumer owing to closure during lockdown led to decreased sales of the market.
Nevertheless, the implementation of vaccination drives and relaxations of government regulations across the globe are assisting the market in reviving.
The polystyrene segment to maintain its lead position during the forecast period

Based on polymer type, the polystyrene segment contributed to the highest share in 2020, holding nearly one-third of the global styrenics market, and is estimated to maintain its lead position during the forecast period. The increase in demand for various disposable household products, electronic gadgets, and automobile has increased the demand for polystyrene market. However, the styrene butadiene rubber segment is estimated to register the highest CAGR of 6.5% from 2021 to 2030. The SBR has various applications in automobile industry as a pneumatic tire, in construction sector as a waterproofing, sealing and binding agent. It is also used as a binder in li-ion batteries.

The automotive segment to maintain its dominant share during the forecast period

Based on application, the automotive segment held the highest share in terms of revenue in 2020, accounting for around one-third of the global styrenics market, and is projected to maintain its dominant share during the forecast period. This is attributed to the increase in demand of various transport vehicles especially in personal vehicle and industrial trucks, forklifts and other. However, the building and construction segment is projected to manifest the largest CAGR of 7.5% from 2021 to 2030, owing rapid growth in population and increase in demand for various constructional activities around the world.

Asia-Pacific, followed by North America, to grow at the fastest CAGR

Based on region, Asia-Pacific, followed by North America, is estimated to witness the fastest CAGR of 6.7% during the forecast period. In addition, the region has also accounted for the highest market share in 2020, contributing to nearly half of the global styrenics market, and is expected to maintain its leadership status by 2030. This is due to investments in developing variety of infrastructure such as transport, smart cities, and food storage in this region.

Leading Market Players

Royal DSM
Sabic
The Dow Chemical Company
Total SA
Repsol SA
Asahi Kasei Corporation
BASF SE
Bayer Material Science
ENI S.P.A
Ineos Group AG

The post Styrenics Market Global Top Industry Players Analysis and Development Trends by 2027, Revenue $134.9 Billion appeared first on Enterprise Viewpoint.

This last major geomagnetic reversal triggered a series of dramatic events that have far-reaching consequences for our planet. They read like the plot of a horror movie: the ozone layer was destroyed, electrical storms raged across the tropics, solar winds generated spectacular light shows (auroras), Arctic air poured across North America, ice sheets and glaciers surged and weather patterns shifted violently.

During these events, life on earth was exposed to intense ultraviolet light, Neanderthals and giant animals known as megafauna went extinct, while modern humans sought protection in caves.

The magnetic north pole – where a compass needle points to – does not have a permanent location. Instead, it usually wobbles around close to the geographic north pole – the point around which the Earth spins – over time due to movements within the Earth’s core.

For reasons still not entirely clear, magnetic pole movements can sometimes be more extreme than a wobble. One of the most dramatic of these pole migrations took place some 42,000 years ago and is known as the Laschamps Excursion – named after the village where it was discovered in the French Massif Central.

The Laschamps Excursion has been recognised around the world, including most recently in Tasmania, Australia. But up until now, it has not been clear whether such magnetic changes had any impacts on climate and life on the planet. Our new work draws together multiple lines of evidence that strongly suggest the effects were indeed global and far-reaching.

Ancient trees

To investigate what happened, we analysed ancient New Zealand kauri trees that had been preserved in peat bogs and other sediments for more than 40,000 years. Using the annual growth rings in the kauri trees, we have been able to create a detailed timescale of how Earth’s atmosphere changed over this time. The trees revealed a prolonged spike in atmospheric radiocarbon levels caused by the collapse of Earth’s magnetic field as the poles switched, providing a way of precisely linking widely geographically dispersed records.

“The kauri trees are like the Rosetta Stone, helping us tie together records of environmental change in caves, ice cores, and peat bogs around the world,” says professor Alan Cooper, who co-lead this research project.

Using the newly-created timescale, we were able to show that tropical Pacific rain belts and the Southern Ocean westerly winds abruptly shifted at the same time, bringing arid conditions to places like Australia at the same time as a range of megafauna, including giant kangaroos and giant wombats went extinct. Further north, the vast Laurentide Ice Sheet rapidly grew across the eastern US and Canada, while in Europe the Neanderthals spiralled into extinction.

Climate modelling

Working with a computer programme that simulated the global interactions between chemistry and the climate, we investigated the impact of a weaker magnetic field and changes in the Sun’s strength. Importantly, during the magnetic switch, the strength of the magnetic field plummeted to less than 6% of what it is today. A compass back then would struggle to even find north.

With essentially no magnetic field, our planet totally lost its very effective shield against cosmic radiation, and many more of these very penetrating particles from space could access the top of the atmosphere. On top of this, the Sun experienced several “grand solar minima” throughout this period, during which the overall solar activity was generally much lower but also more unstable, sending out numerous massive solar flares that allowed more powerful ionising cosmic rays to reach Earth.

Our models showed that this combination of factors had an amplifying effect. The high energy cosmic rays from the galaxy and also enormous bursts of cosmic rays from solar flares were able to penetrate the upper atmosphere, charging the particles in the air and causing chemical changes that drove the loss of stratospheric ozone.

The modelled chemistry-climate simulations are consistent with the environmental shifts observed in many natural climate and environmental change archives. These conditions would have also extended the dazzling light shows of the aurora across the world – at times, nights would have been as bright as daytime. We suggest the dramatic changes and unprecedented high UV levels caused early humans to seek shelter in caves, explaining the apparent sudden flowering of cave art across the world 42,000 years ago.

It must have seemed like the end of days.

The Adams Event

Because of the coincidence of seemingly random cosmic events and the extreme environmental changes found around the world 42,000 years ago, we have called this period the “Adams Event” – a tribute to the great science fiction writer Douglas Adams, who wrote The Hitchhiker’s Guide to the Galaxy and identified “42” as the answer to life, the universe and everything. Douglas Adams really was onto something big, and the remaining mystery is how he knew?

This article was originally published in The conversation. Re published under Creative commons.

The post The Big Breakdown of Earth’s Magnetic Field and the climate change followed 42000 year ago appeared first on Enterprise Viewpoint.

The reports coming out of the country this week are also not good, as the number of cases is steadily increasing from last week.

Despite the government’s warning, many tourists, including Americans are flying to the country many carrying the virus unknowingly. To test and quarantine all these tourists is a humungous job for the government.

Amidst this chaos what is becoming a key tool for the country in effectively testing the tourists with available resources and infrastructure is Eva, a machine learning platform Kimon Drakopoulos, and Vishal Gupta two data scientists at USC Marshall School of Business developed this summer along with Hamsa Bastani, an assistant professor of operations, information and decisions from the Wharton School at the University of Pennsylvania; Jon Vlachogiannis, founder of AgentRisk; and the Greek government.

“We built an artificial intelligence system to help Greece safely reopen its borders to over 80,000 tourists a day. The system, known as Eva, determined which foreign visitors to admit and who to target for testing. As schools, businesses, and tourist destinations navigate a new wave of coronavirus cases amid the busy holiday season, they should consider how to use data and artificial intelligence to deploy their testing resources efficiently and reduce the spread of the virus” Explains Bastani in a recent paper titled “Deploying an Artificial Intelligence System for COVID-19 Testing at the Greek Border,”

The results show that Eva has been 1.85 times efficient than the conventional random checking of passengers. “Our work paves the way for leveraging [artificial intelligence] and real-time data for public health goals, such as border control during a pandemic,” the paper stated. With the rapid spread of a new coronavirus strain, Eva also holds the promise of maximizing the already overburdened testing infrastructure in most countries.

“The main issue was, given the fixed budget for tests, whether we could conduct the tests in a smarter way with dynamic surveillance to identify more infected travelers,” said Bastani

The post Eva: The new AI Champion of Greece in Testing Covid-19 appeared first on Enterprise Viewpoint.

Description: CBD can treat several severe health conditions, which is why it is legal in some countries and can be purchased in the pharmacy. This article will tell you the details about CBD for diabetes.

For centuries, hemp has been used as a pain reliever to improve mood and appetite. The results of a new study say cannabidiol has a positive effect on blood sugar levels, which means it can potentially be used for diabetes. How to take CBD to relieve diabetes symptoms? We will tell you the results of CBD researches, which show the benefits of CBD for diabetes. Stay tuned to learn more.

What is Diabetes Mellitus?

There are two types of diabetes. In type 1 diabetes (D1), the body stops producing insulin. Insulin is a vital hormone secreted by certain cells of the pancreas, the so-called islets of Langerhans. This hormone is responsible for supplying the body’s cells with sugar (glucose), thereby providing them with the most important energy supply. In type II disease (D2), which is often called senile diabetes, insulin is produced sufficiently. Still, the body’s cells do not react to it properly, become resistant, and do not receive the necessary glucose.

What are the Known Risk Factors for Diabetes?

In the origin of type 1 diabetes, genetic predisposition and environmental characteristics are intertwined. More than 20 pairs of genes have been identified, the presence of which forms this type of disease. Overweight is the determining factor in type 2 diabetes.

In obese people, resistance to the hormone insulin is easily formed, primarily muscle and liver cells respond poorly to blood sugar regulation. With a high probability, genetic predisposition also plays a role in forming D2, involving many genes.

The next factor that objectively affects the formation of senile diabetes is an increase in sugar production by its liver. This often happens under the direct influence of stress hormones – adrenaline and cortisol.

A lack of vitamin D and melatonin hormone certainly increases the risk of developing type 2 diabetes. Inflammatory processes have a substantial part in the onset of this form of the disease.

What does CBD Do for Diabetes?

One of the active substances in hemp, cannabidiol, has several unique properties, reviewed at CBD syrup in details. Scientists at the largest educational and scientific center in Jerusalem, the Hebrew University, suggested that it could be used to treat diseases such as diabetes.

Previous research began as early as 1964 when Dr. Raphael Meshulam isolated the main active ingredient in cannabis, THC (tetrahydrocannabinol). 24 years later, he also suggested that THC interacts with special receptors in nerve cells. These receptors were studied and described by him.

This discovery became the basis for many studies. Among other things, it turned out that cannabidiol can relieve diabetes early symptoms. British scientists also formulated this theory; in 2012, an experiment was already conducted on volunteers. Before that, the same laboratory conducted tests on animals – the results were stunning. So how does CBD work for diabetes? It turned out that the active substances in cannabis, especially cannabidiol, can suppress appetite for a short time. In laboratory mice, the metabolic rate increased, due to which the concentration of fats in the liver decreased.

Earlier, Japanese and American scientists explained the well-known fact that consuming CBD for diabetes reduces sugar cravings. This is because there are receptors in the taste buds, the same ones that Raphael Meshulam spoke about, and, thanks to cannabidiol, the perception of a sweet taste is enhanced. In 2018, one of the American medical papers published an article about the experiments conducted at the Medical College in Virginia. Experiments on rats have shown that permanent use of CBD for diabetes treatment can improve diabetic retinopathy (reduced visual acuity up to blindness). It showed that CBD can reduce the diabetic weakening of the heart muscle (USA, Switzerland, Israel). It has a vasodilator effect and relieves neuropathic pain.

In the USA, Europe, and Israel, clinical trials are being carried out, aiming to study the safety of cannabidiol for humans and the optimal dosage. In the future, it is planned to use the substance for the treatment of several chronic diseases, including both types of diabetes.

Conclusion

There is a lot of information in the medical literature on the direct effects of cannabidiol on blood sugar. This information is sometimes contradictory. Despite the lack of study, there are already many separated reports from diabetics that CBD pills for diabetes cure can help stabilize blood sugar levels. One of the suggested ways of action is a decrease in the production of catecholamine and stress hormones (glucocorticoids) by the body under the impact of CBD.

Do you use CBD for diabetes? What is your favorite benefit of consuming cannabidiol? Please share your thought in the comments below.

About the author

Rachel Hudson, EV Contributor – ‘Chele’ is a journalist and vegan, a lover of organic products, and various supplements. She loves to test new useful combinations and post the results on her blog. Chele knows a lot about CBD oil because it helped her quit smoking, improve sleep, and recover from hard workouts.

The post Cannabidiol and Diabetes: Using CBD Oil to Rebalance Blood Sugar appeared first on Enterprise Viewpoint.

Cigarette smoking has been in the limelight for centuries now. Believe it or not, there was a time when everyone believed smoking cigarettes was a relaxation habit, but as science progressed, it was discovered that it caused more harm than good. On that same note, we now know the repercussions of smoking tobacco cigs.

Unfortunately, quitting smoking is better said than done, but now using CBD cigarettes, a tobacco-free world might be nearer than we thought. Wondering what CBD cigarettes are? In simple terms, they are just like traditional cigarettes with only cannabidiol minus all the other harmful traditional cigarette ingredients like nicotine and tar.

That said, let’s find out the ten best cannabidiol cigs brands in the market.

1. Sweet Cake

This brand offers special CBD cigarettes with a well-thought blend of earth, gelato, and cake flavors that stimulate the senses. These cannabidiol cigarettes are immaculately sealed in a glass tube, and each joint has 0.6 grams of organic hemp and crutches. The cannabidiol concentration is at 18.5% and is from an Indica strain of the hemp. It is best for sleep induction, relaxation, and pain relief.

2. Dough Boy

This brand of CBD cigarettes consists of hybrid cigs available in either a 7-pack or a 2-pack. One Dough Boy has 0.6 grams of organic hemp with an 85 milligram content of cannabidiol. Also sealed in a glass tube, this CBD cigarette is perfect for a relaxation session. The terpene formulation consists of an earthy scent, creamy aroma, and a sweet smell.

3. Sour Gummi

Sour Gummi is one of the best CBD cigarettes, and it is also a hybrid strain available in a 2-count pack. Each joint has a CBD content of 16.9% flavored with sour, fruity, and sweet aromas when lit up. The total cannabinoids percentage for each cig is 21.7%. The sour Gummi is perfect for a boost of mood to get you focused and productiv

4. Plain Jane

The Plain Jane CBD cigarettes come in 2-pack, 10-pack, or 20-pack, each stick having a 72 mg CBD content. This brand has an odorless aroma that is great for staying conspicuous. One of the CBD cigarettes health effects Plain Jane offers is fewer toxins’ inhalation. It is excellent for outdoor smoking due to the reduced odor effect.

5. Mr. Rainbow

Mr. Rainbow is a great hybrid mood booster that comes in either a 2-count or 7-count package. The joints are well stuffed in a glass tube and have a CBD content of 22.3%. The 0.6 g joint also has 24.2% cannabinoids. The tastes used in these CBD cigarettes are cream, haze, and cookies.

6. Frosted Kush

This brand is an Indica strain purchased in either 2-count or 7-count casings. Sticks are enclosed in a glass tube, and each weighs 0.6 g with a 19.5% CBD content. When burned, they give out berries and cupcakes aromas.

7. Papaya Nights

Papaya Nights is a Sativa strain designed for relaxation with the tropical fruit, earthy and sweet scents. The glass sealed CBD cigarettes; each has 76 mg cannabidiol content with 95 mg cannabinoids. They each weigh 0.6g.

8. The Secret OG

An Indica strain with four distinctive aromas, kush, bubblegum, diesel, the Secret OG is available in a 2-count or 7-count packet. The cannabidiol content per joint is 18%, and the available cannabinoids are 19%. The Secret OG is perfect for a chilling session.

9. Colorado Hemp Sticks

This brand has a catchy flavor majorly of hemp, which gives it a natural feel as you smoke into relaxation. The Colorado Hemp Sticks have a shallow THC content at 0.3%, which provides you with a mild high feeling. Each packet comes with 20 joints.

10. LiveHemiply

One packet of LiveHempily comes with 20 CBD cigarettes, each containing 25 mg of CBD. The hemp used is GMO-free. They are highly potent and handy for pain relief, inflammation, and curb anxiety and depression.

Conclusion

If you compare the use of CBD cigs and tobacco cigs, CBD cigarettes are safe for you. They have fewer toxins in their composition and offer you extra benefits like relaxation, pain relief, pain relief, and quitting tobacco cigarettes.

Do CBD cigarettes work? Yes, they do! Just make sure you have the best CBD content for your condition and smoke the problem away!

About the author

Rae Hudson, EV Contributor

Rae Hudson tried to quit smoking tobacco cigarettes for three years. But all that changed after she gave CBD cigarettes a try. So far, she has reduced her smoking habit and hopes to eliminate it by the end of the year entirely.

The post The Ultimate Guide: 10 Best CBD Cigarettes In The World Right Now appeared first on Enterprise Viewpoint.

And no….!!! we are not talking about the obvious ones. The legalization of cannabis has literally opened many doors for new industries revolving around the plant. The CBD, one of the hundreds of substances found in cannabis, has established itself as the leader among them.

Find out all about CBD and it’s market value from this infographic put together by LoudCloudHealth.com

The post What and How big is CBD Industry? appeared first on Enterprise Viewpoint.

Around the globe, nanobots are developed to take care of a variety of surgical needs; human interference may become only secondary to them shortly. With this in mind, it is safe to bet nanotechnology holds a vital place in the future of health-tech.

Without further ado, let us look at this infographic put together by Best Health Degrees.

The post Is Nanotechnology The Key to Next-Gen Medidicines? appeared first on Enterprise Viewpoint.

The post Medical Marijuana Laws Improve Health And Reduce Alcohol Use For Certain Groups, Study Finds appeared first on Enterprise Viewpoint.

The study published in The Nature states that the particular mutation increases insulin secretion by stopping zinc from entering cells and locking down insulin. The mutation is seen in at least 0.2 % of the Finnish population(it was slightly more in the western Finland region), whereas it only seen in 0.02% in other europian regions. A team of scientists from the UK, USA, Italy, Sweden, and Finland recruited relatives of the identified careers to carry out the test. The mutation was already known to reduce the probability of type 2 diabetics in careers but it was not clear how until now.

The Advancement of this study opens up new possibilities in diabetic treatments. Drugs that can block zinc transporter proteins can mimic the effect of the mutation. The study was partly funded by US biotech Regeneron Pharmaceuticals and big pharma Pfizer and may hold commercial rights over the findings.

“The work is a collaborative effort bringing pharma and academia together and researchers from multiple European countries,” stated Anna Gloyn, who co-led the study as a Professor at the Welcome Centre for Human Genetics, University of Oxford, UK. “It is a tour de force since we were able to measure the impact of the mutation in many different systems, including human beta-cells.”
At present diabetics, treatments are largely limited to helping patients control their blood glucose levels, and include metformin and Novo Nordisk’s blockbuster liraglutide. The diabetic market is said to become a massive $70 Billion industry by 2026. What impact this study will bring to the industry and how those giants will gain the advantage over it is not conclusive at the moment.

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